Oleg Melnyk
Protein total synthesis

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The Protein Chemical Synthesis (PCS) database has been launched and can be consulted on a dedicated website: http://pcs-db.fr
Native chemical ligation and extended methodologies are the most popular chemoselective reactions for protein chemical synthesis. Their combination with desulfurization techniques can give access to small or challenging proteins that are exploited in a large variety of research areas. In this report, we have conducted a statistical review of their use for protein chemical synthesis in order to provide a flavor of the recent trends and identify the most popular chemical tools used by protein chemists. To this end, a Protein Chemical Synthesis (PCS) database was created by collecting a set of relevant data from more than 450 publications covering the period 1994-2017.

Oleg Melnyk will attend the next Iberian Peptide Meeting as an invited speaker. It is organized in the auditorium of the Barcelona Biomedical Research Park (PRBB) from the 5th to the 7th of February, 2018. This meeting is designed to assemble the Iberian (Spanish-Portuguese) peptide community along with the Spanish Chemical Biology community into an international conference.