Oleg Melnyk
Protein total synthesis

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Home > Publications > Articles

2016-2017

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A simple and traceless solid phase method simplifies the assembly of large peptides and the access to challenging proteins
Ollivier, N., Desmet, R., Drobecq, H., Blanpain, A., Boll, E., Leclercq, , Mougel, A., Vicogne, J. and Melnyk, O. Chem. Sci. 2017 in press
DOI: 10.1039/C7SC01912B


A statistical view of protein chemical synthesis using NCL and extended methodologies
Agouridas, V., El Mahdi, O., Cargoët, M. Melnyk, O. Bioorg. Med. Chem. 2017 in press.
DOI:10.1016/j.bmc.2017.05.050


Protein chemical synthesis by SEA ligation
Melnyk, O.; Vicogne, J.; Simonneau, C., In Chemical Ligation. Tools for Biomolecule Synthesis and Modification, D’Andrea, L. D.; Romanelli, A., Eds. John Wiley & Sons: New York, USA, 2017; pp 161-218.
DOI: 10.1002/9781119044116.ch2


MoS2/TiO2/SiNW surface as an effective substrate for LDI-MS detection of glucose and glutathione in real samples
Hamdi, A.; Hosu, I. S.; Addad, A.; Hartkoorn, R.; Drobecq, H.; Melnyk, O.; Ezzaouia, H.; Boukherroub, R.; Coffinier, Y., Talanta 2017, 171, 101-107.
DOI: 10.1016/j.talanta.2017.04.061


Characterization of peptide attachment on silicon nanowires by X-ray photoelectron spectroscopy and mass spectrometry
Kurylo, I.; Dupre, M.; Cantel, S.; Enjalbal, C.; Drobecq, H.; Szunerits, S.; Melnyk, O.; Boukherroub, R.; Coffinier, Y., Analyst 2017, 142, 969-978.
DOI: 10.1039/C6AN02588A


Kinetically controlled chemoselective cyclization simplifies the access to cyclic and branched peptides
Boll, E., Drobecq, H., Lissy, E., Cantrelle, F.-X., Melnyk, O. Org. Lett. 2016, 18, 3842-3845.
DOI: 10.1021/acs.orglett.6b01847.

Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates
Raibaut, L.; Cargoët, M.; Ollivier, N.; Chang, Y. M.; Drobecq, H.; Boll, E.; Desmet, R.; Monbaliu, J.-C. M.; Melnyk, O. Chem. Sci. 2016, 7, 2657-2665.
DOI: 10.1039/C5SC03459K


Cysteine 52 is the Achilles’ heel of SUMO-1
Drobecq, H. ; Boll, E. ; Sénéchal, M. ; Desmet, R. ; Saliou, J. M. ; Lacapère, J.-J. ; Mougel, A. ; Vicogne, V. ; Melnyk, O. Bioconjugate Chem. 2016, 27 1540–1546.
DOI: 10.1021/acs.bioconjchem.6b00211

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Insight into the SEA amide thioester equilibrium. Application to the synthesis of thioesters at neutral pH
Pira, S. L., El Mahdi, O., Raibaut, L., Drobecq, H., Dheur, J., Boll, E., and Melnyk, O. Org. Biomol. Chem. 2016, 14, 7211-7216.
DOI : 10.1039/C6OB01079B


Total chemical synthesis of SUMO proteins
Melnyk, O.; Vicogne, J. Tetrahedron Letters 2016, 39, 4319–4324.
DOI: 10.1016/j.tetlet.2016.08.035