2014-2015


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Selectively Activatable Latent Thiol and Selenolesters Simplify the Access to Cyclic or Branched Peptide Scaffolds
Raibaut, L.; Drobecq, H.; Melnyk, O. Org. Lett. 2015, 17, 3636–3639.
DOI : 10.1021/acs.orglett.5b01817

 


Synthesis of unprotected linear or cyclic O-acyl isopeptides in water using bis(2-sulfanylethyl)amido peptide ligation
Desmet, R. ; Pauzuolis, M.; Boll, E.; Drobecq, H.; Raibaut, L.; Melnyk, O. Org. Lett. 2015, 17, 3354-3357.
DOI: 10.1021/acs.orglett.5b01614

 


One-pot chemical synthesis of small ubiquitin-like modifier (SUMO) protein-peptide conjugates using bis(2-sulfanylethyl)amido peptide latent thioester surrogates
Boll, E.; Drobecq, H.; Ollivier, N.; Blanpain, A.; Raibaut, L.; Desmet, R.; Vicogne, J. & Melnyk, O. Nat. Protocols
2015, 10, 269-292.

DOI: 10.1038/nprot.2015.013

 


Solid phase protein synthesis
Raibaut, L., El Madhi, O., Melnyk, O. Topics Curr. Chem. 2015, 363, 103-154.

DOI: 10.1007/128_2014_609

 


Access to large cyclic peptides by a one-pot two peptide segments ligation/cyclization process
Boll, E. ; Ebran, J.-P.; Drobecq, H.; El-Mahdi, O.; Raibaut, L.; Ollivier, N.; Melnyk, O. Org. Lett. 2015, 17, 130-133.
DOI: 10.1021/ol503359w

 


Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist
Simonneau, C.; Leclercq, B.; Mougel, A.; Adriaenssens, E.; Paquet, C.; Raibaut, L.; Ollivier, N.; Drobecq, H.; Marcoux, J.; Cianférani, S.; Tulasne, D.; De Jonge, H.; Melnyk, O.; Vicogne, J.
Chem. Sci., 2015,6, 2110-2121.

DOI: 10.1039/C4SC03856H


From protein total synthesis to peptide transamidation and metathesis: Playing with the reversibility of N,S- or N,Se-acyl migration reactions
Melnyk, O.; Agouridas, V. Curr. Opin. Chem. Biol. 2014, 22, 137-145.

DOI : 10.1016/j.cbpa.2014.09.030

 


Selenopeptide Transamidation and Metathesis
Ollivier, N.; Blanpain, A.; Boll, E.; Raibaut, L.; Drobecq, H.; Melnyk, O. Org. Lett. 2014, 16, 4032-4035.
This article is opensource on the following link 12 months after publication date:DOI:10.1021/ol501866j

This article can also be downloaded from our article repository here

 


Tidbits for the synthesis of bis(2-sulfanylethyl)amido (SEA) polystyrene resin, SEA peptides and peptide thioesters
Ollivier, N.; Raibaut, L.; Blanpain, A.; Desmet, R.; Dheur, J.; Mhidia, R.; Boll, E.; Drobecq, H.; Pira, S. L., Melnyk, O. J. Pep. Sci. 2014, 20, 92-97.

DOI 10.1002/psc.2580

 


Decoration of silicon nanostructures with copper particles for simultaneous selective capture and mass spectrometry detection of His-tagged model peptide
Coffinier, Y.; Kurylo, I.; Drobecq, H.; Szunerits, S.; Melnyk, O.; Zaitsev, V. N.; Boukherroub, R. Analyst 2014,

DOI: 10.1039/C4AN01056F

 


Perhydro-1,2,5-dithiazepine
Melnyk, O. ; Agouridas, V. eROS, article RN01723

DOI : 10.1016/j.cbpa.2014.09.030

 


A novel PEG-based solid support enables the synthesis of > 50 amino acids peptide thioesters and the total synthesis of a functional SUMO-1 peptide conjugate
Boll, E.; Drobecq, H.; Ollivier, N.; Raibaut, L.; Desmet, R.; Vicogne, J.; Melnyk, O Chem. Sci. 2014, 5, 2017-2022.
This article is opensource on the following link:
DOI: 10.1039/C3SC53509F

This article can also be downloaded from our article repository here

 


Phenylthiocarbamate or N-carbothiophenyl group chemistry in peptide synthesis and bioconjugation
Melnyk, O.; Ollivier, N.; Besret, S.; Melnyk, P. Bioconjugate Chem. 2014, 25, 629-639.
This article is opensource on the following link 12 months after publication date:DOI: 10.1021/bc500052r

This article can also be downloaded from our article repository here

 


Thiocarbamate-linked polysulfonate-Peptide conjugates as selective hepatocyte growth factor receptor binders
Besret, S. ; Vicogne, J. ; Dahmani, F. ; Fafeur, V. ; Desmet, R. ; Drobecq, H. ; Romieu, A.; Melnyk, P.; Melnyk, O. Bioconjugate Chem. 2014, 25, 1000-1010.
This article is opensource on the following link 12 months after publication date:DOI: 10.1021/bc500137j

This article can also be downloaded from our article repository here