The Melnyk Group

Par en May 2017

A simple and traceless solid phase method simplifies the assembly of large peptides and the access to challenging proteins
Ollivier, N., Desmet, R., Drobecq, H., Blanpain, A., Boll, E., Leclercq, , Mougel, A., Vicogne, J. and Melnyk, O. Chem. Sci. 2017 in press
DOI: 10.1039/C7SC01912B

A statistical view of protein chemical synthesis using NCL and extended methodologies
Agouridas, V., El Mahdi, O., Cargoët, M. Melnyk, O. Bioorg. Med. Chem. 2017 in press.
DOI:10.1016/j.bmc.2017.05.050

Protein chemical synthesis by SEA ligation
Melnyk, O.; Vicogne, J.; Simonneau, C., In Chemical Ligation. Tools for Biomolecule Synthesis and Modification, D’Andrea, L. D.; Romanelli, A., Eds. John Wiley & Sons: New York, USA, 2017; pp 161-218.
DOI: 10.1002/9781119044116.ch2

MoS2/TiO2/SiNW surface as an effective substrate for LDI-MS detection of glucose and glutathione in real samples
Hamdi, A.; Hosu, I. S.; Addad, A.; Hartkoorn, R.; Drobecq, H.; Melnyk, O.; Ezzaouia, H.; Boukherroub, R.; Coffinier, Y., Talanta 2017, 171, 101-107.
DOI: 10.1016/j.talanta.2017.04.061

Characterization of peptide attachment on silicon nanowires by X-ray photoelectron spectroscopy and mass spectrometry
Kurylo, I.; Dupre, M.; Cantel, S.; Enjalbal, C.; Drobecq, H.; Szunerits, S.; Melnyk, O.; Boukherroub, R.; Coffinier, Y., Analyst 2017, 142, 969-978.
DOI: 10.1039/C6AN02588A

Kinetically controlled chemoselective cyclization simplifies the access to cyclic and branched peptides
Boll, E., Drobecq, H., Lissy, E., Cantrelle, F.-X., Melnyk, O. Org. Lett. 2016, 18, 3842-3845.
DOI: 10.1021/acs.orglett.6b01847.

Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates
Raibaut, L.; Cargoët, M.; Ollivier, N.; Chang, Y. M.; Drobecq, H.; Boll, E.; Desmet, R.; Monbaliu, J.-C. M.; Melnyk, O. Chem. Sci. 2016, 7, 2657-2665.
DOI: 10.1039/C5SC03459K

Cysteine 52 is the Achilles’ heel of SUMO-1
Drobecq, H. ; Boll, E. ; Sénéchal, M. ; Desmet, R. ; Saliou, J. M. ; Lacapère, J.-J. ; Mougel, A. ; Vicogne, V. ; Melnyk, O. Bioconjugate Chem. 2016, 27 1540–1546.
DOI: 10.1021/acs.bioconjchem.6b00211

Inside cover

Insight into the SEA amide thioester equilibrium. Application to the synthesis of thioesters at neutral pH
Pira, S. L., El Mahdi, O., Raibaut, L., Drobecq, H., Dheur, J., Boll, E., and Melnyk, O. Org. Biomol. Chem. 2016, 14, 7211-7216.
DOI : 10.1039/C6OB01079B

Total chemical synthesis of SUMO proteins
Melnyk, O.; Vicogne, J. Tetrahedron Letters 2016, 39, 4319–4324.
DOI: 10.1016/j.tetlet.2016.08.035