Recent papers including in press papers & openscience archives (2020-)

Highlights: Nat. Commun. 2020, Org. Lett. 2020, J. Med. Chem. 2020


Home > Publications > Recent papers including in press papers & openscience archives (2020-)

Par en December 2020


N,S- and N,Se-acyl transfer devices in protein synthesis
Diemer, V. ; Bouchenna, J. ; Kerdraon, F. ; Agouridas, V. ; Melnyk, O.
In Total Chemical Synthesis of Proteins, A. Brik, P. Dawson, L. Liu, eds., 2021, scheduled April 2021

Preprint


Chemical Protein Synthesis in Medicinal Chemistry
Agouridas, V.; El Mahdi, O.; Melnyk, O. . J Med Chem 2020, asap.
DOI: 10.1021/acs.jmedchem.0c01082
Although the majority of proteins used for biomedical research are produced using living systems such as bacteria, biological means for producing proteins can be advantageously complemented by protein semisynthesis or total chemical synthesis. The latter approach is particularly useful when the proteins to be produced are toxic for the expression system or show unusual features that cannot be easily programmed in living organisms. The aim of this review is to provide a wide overview of the use of chemical protein synthesis in medicinal chemistry with a special focus on the production of post-translationally modified proteins and backbone cyclized proteins.

Preprint


A Cysteine Selenosulfide Redox Switch for Protein Chemical Synthesis
Diemer, V.; Ollivier, N.; Leclercq, B.; Drobecq, H.; Vicogne, J.; Agouridas, V.; Melnyk, O. Nat. Commun. 2020, 2558.
Pdf in open access here

DOI: 10.1038/s41467-020-16359-6

The editors at Nature Communications have put together an Editors’ Highlights webpage of research on Organic Chemistry and Chemical Biology published in May 2020 and have chosen to feature our article:

 


Comment on « N-terminal Protein Tail Acts as Aggregation Protective Entropic Bristles : The SUMO Case »
Sénéchal, M.; Bouchenna, J.; Vicogne, J.; Melnyk, O. Biomacromolecules 2020, 8, 3480-3482.
DOI: 10.1021/acs.biomac.0c00185

Preprint. Posted on ChemRxiv 07 Feb. 2019



Natural T cell epitope containing methyl-lysines on mycobacterial heparin-binding hemagglutinin
Corbière, V. ; Segers, J. ; Desmet, R. ; Lecher, S. ; Loyens, M. ; Petit, E. ; Melnyk, O. ; Locht, C. ; Mascart, F. J. Immunol. J Immunol 2020, 204, 1715-1723.

DOI: 10.4049/jimmunol.1901214



Strategies and open questions in solid phase protein chemical synthesis
Agouridas, V.; Diemer, V.; Melnyk, O.

Curr. Opin. Chem. Biol. 2020, 58, 1-9.
DOI: 10.1016/j.cbpa.2020.02.007



SEA Ligation is accelerated at Midly Acidic pH. Application to the Formation of Difficult Peptide Junctions
Cargoët, M.; Diemer, V.; Raibaut, L.; Lissy, E.; Snella, B.; Agouridas, V.; Melnyk, O.
Springer Protocols Handbooks, Olga Iranzo and Ana CecĂ­lia Roque (Eds): Peptide and Protein Engineering, 978-1-0716-0719-0, 2020, 1-12.

Also on ChemRxiv
ChemRxiv. Preprint. posted on ChemRxiv 23 Dec 2019

 



The problem of aspartimide formation during protein chemical synthesis using SEA-mediated ligation
Bouchenna, J.; Sénéchal, M.; Drobecq, H.; Vicogne, V.; Melnyk, O. ChemRxiv.
Springer Protocols Handbooks, Olga Iranzo and Ana CecĂ­lia Roque (Eds): Peptide and Protein Engineering, 978-1-0716-0719-0, 2020, 13-28.

Also on ChemRxiv
Preprint. Posted on ChemRxiv 23 Dec 2019

 



Using the interactive tool of The Protein Chemical Synthesis Database
Agouridas, V.; Melnyk, O.
Springer Protocols Handbooks, Olga Iranzo and Ana CecĂ­lia Roque (Eds): Peptide and Protein Engineering, 978-1-0716-0719-0, 2020, 29-36.

PCS-db protocol