Ligation chemistry

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Ligation chemistries are essential tools in chemical biology research. They enable the synthesis of complex scaffolds for a variety of applications. Chemoselective ligation chemistries leading to the formation of native peptide bonds are essential tools for protein total synthesis.
We hope that these pages will help you understanding the importance of this research field and may be synthesizing your own molecules!

SEA chemistry essentials

Synthesis of peptide thioesters

One-pot three peptide segments assembly strategy


SEA ligation at proline

Synthesis of peptide thioacids